First RNA-Seq Liquid Biopsy Blood Test

We have newly discovered a hyper-active Region of Interest on the human genome, revealed by querying unmapped reads. These reads are routinely discarded as “junk RNA” or “contamination” because their functions are poorly understood.

The ncRNA sequences homologous to our proprietary Region of Interest database are biomarkers for neurologic diseases with very strong signal to noise.

AACC Annual Scientific Meeting & Clinical Lab Expo 2021

FBB Biomed Technology Featured Again at AACC Annual Meeting

RNA vs. DNA Diagnostics

RNA offers two key advantages over DNA: First, it is far more abundant than DNA in human tissue, which means it is easier to build more accurate diagnostics due to higher nucleic acid yield.

Second, due to RNA’s functional and regulatory role in molecular processes, RNA makes real-time diagnostics possible, while DNA only allows for risk stratification.

ncRNA Biomarkers

The advancement of sequencing hardware and bioinformatic software has enabled the discovery and utilization of non-coding RNA (ncRNA) for diagnostic purposes.

We use a combination of proprietary sample enrichment and bioinformatic analysis to filter out and measure our FBB Biomed ncRNA biomarkers for neurologic diseases.

Preliminary Research

Proof-of-Concept Studies

Background: Using the differential expression of ncRNA biomarkers between RRMS patients and controls to provide a screening test for RRMS; Using the differential expression of ncRNA biomarkers between RRMS patients and ALS/AD/PD patients to provide a differential diagnosis test for RRMS

Publication: Abstract peer-reviewed and published by the ACTRIMS Forum in February 2020

ncRNA biomarkers over-expressed: Yes

Potential drug targets detected: Yes

Background: Using the differential expression of ncRNA biomarkers between ALS patients and controls to provide a screening test for ALS

Publication: Unpublished

ncRNA biomarkers over-expressed: Yes

Potential drug targets detected: Yes

Background: Using the differential expression of ncRNA biomarkers between AD patients and controls to provide a screening test for AD

Publication: Unpublished

ncRNA biomarkers over-expressed: Yes

Potential drug targets detected: Yes

Background: Using the differential expression of ncRNA biomarkers between PD patients and controls to provide a screening test for PD

Publication: Unpublished

ncRNA biomarkers over-expressed: Yes

Potential drug targets detected: Yes