First RNA-Seq Liquid Biopsy Blood Test

We have newly discovered a hyper-active Region of Interest on the human genome, revealed by querying unmapped reads. These reads are routinely discarded as “junk RNA” or “contamination” because their functions are poorly understood.

The RNA sequences homologous to our proprietary Region of Interest database are biomarkers for neurologic diseases with very strong signal to noise.

AACC Annual Meeting 2021

FBB Biomed Technology Featured Again at AACC Annual Meeting

RNA vs. DNA Diagnostics

RNA offers two key advantages over DNA: First, it is far more abundant than DNA in human tissue, which means it is easier to build more accurate diagnostics due to higher nucleic acid yield.

Second, due to RNA’s functional and regulatory role in molecular processes, RNA makes real-time diagnostics possible, while DNA only allows for risk stratification.

RNA Biomarkers

The advancement of sequencing hardware and bioinformatic software has enabled the discovery and utilization of ribonucleic acid (RNA) for diagnostic purposes.

We use a combination of proprietary sample enrichment and bioinformatic analysis to filter out and measure our FBB Biomed RNA biomarkers for neurologic diseases.

Workflow

Research

Proof-of-Concept Studies

Background: Using the differential expression of RNA biomarkers between RRMS patients and controls to provide a confirmation test for RRMS; Using the differential expression of RNA biomarkers between RRMS patients and PD/AD patients to provide a differential diagnosis test for RRMS

Publication #1: Wahls, T., Chimenti, M. S., Kamholz, J., & Urnovitz, H. (2020, May). RNA Differential Expression In Serial Blood Samples Of Relapsing Remitting Multiple Sclerosis Patients Correlates With Clinically Reported Flares. MULTIPLE SCLEROSIS JOURNAL (Vol. 26, No. 1_ SUPPL, pp. 81-81). 1 Olivers Yard, 55 City Road, London EC1Y 1SP, England: SAGE Publications Ltd.

Publication #2: Citation not available yet

RNA biomarkers over-expressed: Yes

Potential drug targets detected: Yes

Background: Using the differential expression of RNA biomarkers between PD patients and controls to provide a confirmation test for PD

Publication: Citation not available yet

RNA biomarkers over-expressed: Yes

Potential drug targets detected: Yes

Background: Using the differential expression of RNA biomarkers between AD patients and controls to provide a confirmation test for AD

Publication: Citation not available yet

RNA biomarkers over-expressed: Yes

Potential drug targets detected: Yes